Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity
نویسندگان
چکیده
منابع مشابه
Anticontractile Effect of Perivascular Adipose Tissue and Leptin are Reduced in Hypertension
Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthesized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously hypertensive rats (SHR) might contribute to a diminished paracrine anticontractile effect of the hormone. We have determined in aorta from Wistar-Kyoto (W...
متن کاملDeletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release.
BACKGROUND AND PURPOSE Perivascular adipose tissue (PVAT) surrounds most blood vessels and secretes numerous active substances, including adiponectin, which produce a net anticontractile effect in healthy individuals. AMPK is a key mediator of cellular energy balance and may mediate the vascular effects of adiponectin. In this study, we investigated the role of AMPK within PVAT in mediating the...
متن کاملcGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue.
AIM The aim of this study was to investigate the role of cGMP-dependent protein kinase (PKG) in mediating the anticontractile function of perivascular adipose tissue (PVAT) and whether its activation can rescue PVAT activity which is lost in an experimental model of inflammation. METHODS AND RESULTS Contractile responses to norepinephrine were assessed using wire myography from small arterial...
متن کاملMechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an importa...
متن کاملInterleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice.
RATIONALE Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear. OBJECTIVE To examine the functional role of IL-33 in adipose tissues and investigate the effects on adipose ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2020
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00491.2020